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|
Variables
|
Univariate analysis
|
|---|
|
HR
|
95% CI
|
P
|
|---|
|
Age (< 65 vs. ≥65)
|
1.47
|
0.68–3.17
|
NS
|
|
Gender (female vs. male)
|
0.74
|
0.29–1.84
|
NS
|
|
Stage (I vs. II vs. III)
|
1.64
|
1.00–2.69
|
0.049
|
|
Histology (adeno vs. other)
|
1.50
|
0.69–3.27
|
NS
|
|
Lymph node status (negative vs. positive)
|
2.09
|
0.95–4.60
|
NS
|
|
pT status (pT1a-2b vs. pT3–4)
|
2.65
|
1.25–5.62
|
0.011
|
|
Differentiation (poor vs. well-moderate)
|
0.80
|
0.37–1.75
|
NS
|
|
Smoking (smokers vs. nonsmokers)
|
0.48
|
0.18–1.23
|
NS
|
|
COPD (present vs. absent)
|
1.17
|
0.54–2.55
|
NS
|
|
M1 macrophages in islets (high vs. low)
|
2.83
|
1.20–6.68
|
0.017
|
|
M1 macrophages in stroma (high vs. low)
|
1.91
|
0.86–4.25
|
NS
|
|
Total M1 macrophages (high vs. low)
|
1.43
|
0.63–3.21
|
NS
|
|
M2 macrophages in islets (high vs. low)
|
1.43
|
0.66–1.43
|
NS
|
|
M2 macrophages in stroma (high vs. low)
|
1.00
|
0.73–1.37
|
NS
|
|
Total M2 macrophages (high vs. low)
|
0.31
|
0.13–0.75
|
0.009
|
|
IL-10
|
0.74
|
0.35–1.55
|
NS
|
|
TNF-α
|
1.16
|
0.55–2.45
|
NS
|
|
IFN-γ
|
0.67
|
0.31–1.43
|
NS
|
- HR hazard ratio, CI confidence interval, NS not significant
