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M1 macrophages
|
M2 macrophages
|
|---|
|
Islets
|
Stroma
|
Islets
|
Stroma
|
|---|
|
Gender:
|
|
Female
|
33.5 (10–47)
|
71 (44–100)
|
16.5 (4–41)
|
80.5 (43–112)
|
|
Male
|
26 (10–67)
|
72 (38–111)
|
22 (4–54)
|
89.5 (40–167)
|
|
Age (years):
|
|
< 65
|
29 (10–67)
|
72 (38–108)
|
24 (4–40)
|
90 (40–112)
|
|
≥ 65
|
26 (10–47)
|
72 (41–111)
|
19 (4–54)
|
87 (43–167)
|
|
Smoking status:
|
|
Smokers
|
26 (10–67)
|
74 (38–111)*
|
22.5 (4–54)
|
90 (40–167)*
|
|
Non-smokers
|
32 (10–47)
|
58 (42–100)
|
17.5 (4–41)
|
78.5 (43–104)
|
|
Histological NSCLC type:
|
|
Adenocarcinoma
|
33.5 (10–51)*#
|
64.5 (41–111)
|
22 (4–40)
|
86.5 (43–115)
|
|
Squamous cell carcinoma
|
22.5 (10–67)
|
75.5 (48–101)
|
20.5 (5–54)
|
93.5 (40–167)
|
|
Other
|
27.5 (23–47)
|
69 (38–100)
|
24.5 (11–41)
|
89 (60–99)
|
|
Stage:
|
|
IA-IB
|
26 (10–45)
|
66 (41–111)
|
20 (4–35)
|
95 (60–167)
|
|
IIA-IIB
|
29 (10–45)
|
72 (43–108)
|
23 (4–54)
|
86 (53–119)
|
|
IIIA-IIIB
|
29 (11–67)
|
76 (38–101)
|
20 (5–39)
|
91 (40–109)
|
|
pT status:
|
|
pT1a-2b
|
29 (10–47)
|
71 (41–111)
|
21.5 (4–54)
|
87.5 (53–167)
|
|
pT3–4
|
24 (11–67)
|
75 (38–108)
|
21 (4–41)
|
86.5 (40–108)
|
|
Lymph node status:
|
|
Negative (N0)
|
26 (10–45)
|
64 (41–111)*
|
20 (4–41)
|
90 (60–167)
|
|
Positive (N1-N3)
|
29 (11–67)
|
77 (38–101)
|
22 (5–54)
|
87 (40–119)
|
|
Differentiation:
|
|
Poor
|
26.5 (10–67)
|
71 (41–111)
|
23.5 (4–54)
|
92.5 (43–167)
|
|
Well-moderate
|
29 (10–51)
|
72.5 (38–101)
|
19 (4–40)
|
87 (40–119)
|
|
COPD:
|
|
Present
|
26 (10–67)
|
68.5 (38–111)
|
22 (4–41)
|
87 (40–115)
|
|
Absent
|
29 (15–51)
|
77 (43–101)
|
19 (4–54)
|
90.5 (51–167)
|
- The number of macrophages represents median (range) per ten high-power fields in tumor islets or tumor stroma
- #P < 0.05, Kruskal-Wallis test
- *P < 0.05, Mann-Whitney test for difference between adenocarcinoma and squamous cell carcinoma
